21 Quotes by Aaron Ciechanover
- Author Aaron Ciechanover
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Reticulocytes are terminally differentiating red blood cells that do not contain lysosome. Therefore, it was postulated that the degradation of hemoglobin in these cells is mediated by a non-lysosomal machinery.
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The development of methods to monitor protein dynamics in cells together with the discovery of specific and general lysosomal inhibitors have resulted in the identification of different classes of cellular proteins, long- and short-lived, and the findings of the differential effects of the inhibitors on these groups.
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The evolvement of proteolysis as a centrally important regulatory mechanism is a remarkable example for the development of a novel biological concept and the accompanying battles to change paradigms.
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The important thing is to do what you most love in the best way. If you love literature, you could be a great writer and perhaps one day become a Nobel Prize Laureate for Literature.
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The problem of different sensitivities of distinct protein groups to lysosomal inhibitors has remained unsolved and may have served as an important trigger in the future quest for a non-lysosomal proteolytic system that may be involved in at least certain aspects of intracellular protein degradation.
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The scale of time for a politician runs between one primary and the next, and in Israel, this means two to three years because elections almost never take place once every four years as stipulated by law. The timetable for a system of research is completely different.
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To develop drugs for people, we basically dismantle the system. In the lab, we look at things the size of a cell or two. We dismantle life into very small models.
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Towards the end of the military service, I had to make what I assume has been the most important decision in my career: to start a residency in clinical medicine, in surgery, which was my favorite choice, or to enroll into graduate school and start a career in scientific research. It was clear to me that I was heading for graduate school.
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We are a country that lacks riches. The Jewish brain, that's what we have. Everything that we've had and will have in this country is the direct and clear product of higher education. If we harm this system, we will drastically decline and cease to exist.
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