31 Quotes by David Andrew Sinclair

Only 20 percent of our longevity is genetically determined. The rest is what we do, how we live our lives and increasingly the molecules that we take. It's not the loss of our DNA that causes aging, it's the problems in reading the information, the epigenetic noise.

You want to shock the body and not be constant. Intermittent fasting is an increasingly popular way: Skip breakfast, for example. Also lifting weights, losing your breath from exercise and alternating between hot and cold temperatures. We think these measures will only get us to 100 to 122 years old. That's our natural lifespan.

The way to make a worm live longer is probably quite different from making a human live longer.

We've always known that our bodies are capable of healing themselves under the right conditions: Diet and exercise improve our health. But there are also ancient genetic survival pathways in every living thing.

If I'm not hungry and I'm busy, I am quite happy to skip a meal. It's informal intermittent fasting. I feel strongly that this is one of the strongest areas of longevity research.

Aging is just like any deterioration of the body. It fulfills every category of what we call a disease except one: it impacts more than half the population.

So aging is really just the way we deteriorate over time. Lifespan on the other hand is how long we live. We typically refer to that as longevity.

Unfortunately, because aging is so common and natural, we tend to think of it as destiny or something we should accept.

Resveratrol had a decent benefit when the mice were obese and sedentary. The mice that were fed a lean diet and resveratrol lived significantly longer than other treated mice as well as those that had no healthy diet and no resveratrol. So resveratrol is not an excuse to be lazy or eat whatever you want.