[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fHNEZiiUTk9YuSfTQ7mHv7hW77TuhwLUh-9RB4FjGonE":3,"$fDgqz16mNamOZB3w8zuQv6IagbXNN90c3Bh4JQwAOZyE":12},{"author":4,"tags":11},{"author_id":5,"author_name":6,"author_name_first_letter":7,"article_count":8,"bio":9,"short_bio":9,"slug":10,"image_url":9},177513,"James Rothman","J",9,null,"james-rothman",[],{"quotes":13,"pagination":116},[14,27,38,50,61,72,83,94,105],{"id":15,"quote_text":16,"author_id":5,"source_id":17,"has_image":18,"author":19,"source":20,"quote_tag":21,"commentary":9},2318556,"The truth is that anyone, almost anyone, who receives the Nobel Prize has some indirect knowledge of one sort or another that they may be a candidate.",4,false,{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[22],{"id":23,"tag":24},5301154,{"id":25,"tag_name":26},24218,"almost",{"id":28,"quote_text":29,"author_id":5,"source_id":17,"has_image":18,"author":30,"source":31,"quote_tag":32,"commentary":9},2318542,"I had five years of failure, really, before I had the first initial sign of success.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[33],{"id":34,"tag":35},5301147,{"id":36,"tag_name":37},21426,"firsts",{"id":39,"quote_text":40,"author_id":5,"source_id":17,"has_image":18,"author":41,"source":42,"quote_tag":43,"commentary":49},2318534,"I became aware of the very complex internal organization in a cell from the basic science classes, and it made me think about how all that could work. It seemed like a great mystery, especially how organelles in the cell can be arranged in three dimensions, and how thousands of proteins could find their way to the right location in the cells.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[44],{"id":45,"tag":46},5301132,{"id":47,"tag_name":48},56,"thinking","**The Backstory**\nJames Rothman, a renowned cell biologist and Nobel laureate, likely expressed these sentiments in the context of his early academic career. As a graduate student in the 1970s, Rothman was fascinated by the intricate mechanisms of cellular biology, particularly the organization and function of organelles within cells. His curiosity and wonder at the complexity of cellular organization laid the foundation for his groundbreaking research in vesicle trafficking and membrane fusion.\n\n**The Hidden Insight**\nBeneath the surface of Rothman's admiration for the intricate internal organization of cells lies a profound appreciation for the complexity of systems that operate beyond human comprehension. This quote reveals a subtle tension between the desire for understanding and the limits of human knowledge, highlighting the inherent humility that comes with acknowledging the mysteries of the natural world.\n\n**How to Use This**\nWhen facing complex problems or unfamiliar systems, adopt a mindset of humble curiosity, recognizing that the most profound insights often arise from the interplay between human ingenuity and the inherent complexity of the world. By embracing the mystery, rather than trying to conquer it, you can unlock new perspectives and foster a deeper understanding of the intricate systems that govern our world.",{"id":51,"quote_text":52,"author_id":5,"source_id":17,"has_image":18,"author":53,"source":54,"quote_tag":55,"commentary":9},2318519,"I started taking a basic biology course, and I really loved it. I started asking research questions incessantly. I was drawn very quickly to biology.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[56],{"id":57,"tag":58},5301121,{"id":59,"tag_name":60},2773,"asking",{"id":62,"quote_text":63,"author_id":5,"source_id":17,"has_image":18,"author":64,"source":65,"quote_tag":66,"commentary":9},2318500,"When I was a college student at Yale, I was studying physics and mathematics and was absolutely intent on becoming a theoretical physicist.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[67],{"id":68,"tag":69},5301110,{"id":70,"tag_name":71},75,"college",{"id":73,"quote_text":74,"author_id":5,"source_id":17,"has_image":18,"author":75,"source":76,"quote_tag":77,"commentary":9},2318476,"In the earlier years when I started this project at Stanford University, everyone told me it was nuts to go and try to reproduce the mysterious complexities that occur in a whole cell.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[78],{"id":79,"tag":80},5301089,{"id":81,"tag_name":82},4090,"earlier",{"id":84,"quote_text":85,"author_id":5,"source_id":17,"has_image":18,"author":86,"source":87,"quote_tag":88,"commentary":9},2318452,"As physics students, we are taught that physicists are smart, that chemists are moderately acceptable, and that biologists are certainly not very intelligent. So I wasn't inclined to take a biology course. But my father insisted, and maybe what he had in mind was that, if there were no jobs in physics, I would end up being a doctor.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[89],{"id":90,"tag":91},5301058,{"id":92,"tag_name":93},67941,"biologists",{"id":95,"quote_text":96,"author_id":5,"source_id":17,"has_image":18,"author":97,"source":98,"quote_tag":99,"commentary":9},2318432,"I might have been just as happy to have been a practicing primary-care doctor. But as a medical student, I had interacted with patients suffering from neurodegeneration or acute clinical schizophrenia. It left an indelible mark on my memory.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[100],{"id":101,"tag":102},5301041,{"id":103,"tag_name":104},44638,"acute",{"id":106,"quote_text":107,"author_id":5,"source_id":17,"has_image":18,"author":108,"source":109,"quote_tag":110,"commentary":9},2318419,"One of the major lessons in all of biochemistry, cell biology and molecular medicine is that when proteins operate at the sub cellular level, they behave in a certain way as if they're mechanical machinery.",{"id":5,"author_name":6,"slug":10,"author_name_first_letter":7,"article_count":8,"image_url":9},{},[111],{"id":112,"tag":113},5301026,{"id":114,"tag_name":115},19315,"behave",{"currentPage":117,"totalPages":117,"totalItems":8,"itemsPerPage":118},1,10]