The 4th sort of creatures... which moved through the 3 former sorts, were incredibly small, and so small in my eye that I judged, that if 100 of them lay [stretched out] one by another, they would not equal the length of a grain of course Sand; and according to this estimate, ten hundred thousand of them could not equal the dimensions of a grain of such course Sand. There was discover'd by me a fifth sort, which had near the thickness of the former, but they were almost twice as long. The first time bacteria were observed.
-Antonie van Leeuwenhoek
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