It may very well be that if you were to take all the research funding in the country and you put it in Alzheimer's disease, you would never get to the solution. But the answer to Alzheimer's disease may come from a misfolding protein in a cucumber. But how are you going to write a grant on a cucumber? And who are you going to send it to? If somebody gets interested in a folding protein in a cucumber and it's a good scientific question, leave them alone. Let them torture the cucumber.
-David Epstein
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