As with the other conditions described, the natural history of local tissue damage spreads its effect, including pain, to nearby and distant structures by a linked series of separate mechanisms. This is nowhere more clear than in osteoarthritis, in which the disorder starts locally in a joint but spreads to nearby tissue while the nervous system, attempting to immobilize the joint, generates an abnormal gait and posture, which in turn stresses other joints.
-Patrick Wall
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