Part of the beauty of Silicon Valley is that people generally encourage you to think crazy. It's the hypothesis that there's nothing sacred that can't be changed.

You should know how to take care of yourself. That's one of the things that I got from my mother most - she always said that if you don't take care of yourself, no one will.

When you try new things, you will make mistakes. That's OK.

My mom was a problem solver.

When Amazon emerged, people had these debates about whether people would put their credit cards online.

When I graduated from college in 1996 and the Internet was taking off, I remember this feeling that there was an open range where anything could be built.

It's one of the things I want people to understand about science... You don't have to be the best person in the world at it. But you can be good, and there are so many different opportunities in science.

I have mothers with small children come to me and say, 'You found that I had early breast cancer - because of you, I don't have cancer.' You've just prevented that person from dying early, and to prevent an early, unnecessary death is incredibly meaningful.

My divorce wasn't fun.

People are used to dealing with risk.