These findings are reassuring for women who want to use these hormones around the age of menopause in the short term for the relief of symptoms.

I can see how a lot of women might be confused.

I can see how a lot of women might be confused. People would like very clear results with a very clear health message, and, unfortunately, these results are not very clear.

That is a pretty clear signal that there is still something here. I'm hopeful that we will show significant results as we follow these women longer.

The study is poised to capitalize on the huge advances that have been made in the field of genomics. The best may be yet to come.

These are secondary analyses and are exploratory to some extent.

Based on our findings, we cannot recommend that most women should follow a low-fat diet.

We as scientists need to be responsible in our public health messages, and provide a balance. But the media picked up the message as the fact these trials are overturning conventional wisdom. They haven't.

This study shows that just reducing total fat intake does not go far enough to have an impact on heart disease risk.

We don't see these as null studies. There are strong suggestions the benefits will show themselves.